Global HIV/AIDS Medicine by Paul A. Volberding MD, Merle A. Sande MD, Joep M. A. Lange

By Paul A. Volberding MD, Merle A. Sande MD, Joep M. A. Lange MD, Warner C. Greene MD PhD, Joel E. Gallant MD MPH

HIV/AIDS administration poses many alternative demanding situations around the globe, and the treatments on hand within the West are frequently now not economically possible in constructing nations. This new e-book is the 1st to handle the myriad of medical problems confronted by way of healthiness practitioners all over the world in handling HIV/AIDS. Edited through an analogous gurus accountable for the hugely revered reference "The clinical administration of AIDS," with affiliate Editors that come with the President of the foreign AIDS Society and a preeminent opinion chief within the struggle opposed to AIDS in Africa, and authored through a "who's who" of present international specialists on HIV and AIDS medication, this visionary textual content offers all of the sensible, integral info that clinicians in every single place have to supply their sufferers the very best care.

  • Access trustworthy, up to the moment advice that addresses the realities of HIV/AIDS administration on your nation-state, because of contributions from an international solid of well known specialist clinicians and researchers.
  • Locate the clinically actionable details you would like speedy with a company that mirrors the present kingdom of the AIDS epidemic and different wishes of Western vs. developing-world sufferers and clinicians.
  • Diagnose AIDS manifestations optimistically through evaluating them to full-color scientific images.
  • Review crucial information speedy via a number of at-a-glance tables.

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20. Santiago ML, Rodenburg CM, Kamenya S, et al. SIVcpz in wild chimpanzees. Science 2002; 295:465–465. 21. Worobey M, Santiago ML, Keele BF, et al. Origin of AIDS – Contaminated polio vaccine theory refuted. Nature 2004; 428:820–820. 22. Ayouba A, Mauclere P, Martin PMV, et al. HIV-1 group O infection in Cameroon, 1986–1998. Emerging Infect Dis 2001; 7:466–467. 23. Roques P, Robertson DL, Souquiere S, et al. Phylogenetic characteristics of three new HIV-1 N strains and implications for the origin of group N.

37. Vodicka MA, Koepp DM, Silver PA, et al. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev 1998; 12:175–185. 38. Dupont S, Sharova N, DeHoratius C, et al. A novel nuclear export activity in HIV-1 matrix protein required for viral replication. Nature 1999; 402:681–685. 39. Chen H, Engelman A. The barrier-to-autointegration protein is a host factor for HIV type 1 integration. Proc Natl Acad Sci USA 1998; 95:15270–15274. 40. Schroder AR, Shinn P, Chen H, et al.

Rather, virions bound to DC-SIGN may be internalized into a vesicular compartment that does not lead to viral inactivation. 14 Indeed, these virus-laden vesicles may selectively accumulate at the immunological synapse formed between dendritic cells and CD4 T cells. Thus, these dendritic cells expressing DC-SIGN or related Ctype lectin receptors may act as ‘Trojan horses’ that facilitate the spread of HIV from mucosal surfaces to lymphatic organs in the absence of productive infection of the dendritic cell itself.

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