Cytomegalovirus: Biology and Infection by Monto Ho

By Monto Ho

Although there are many first-class present studies on one or one other element of cytomegalovirus, the final accomplished therapy of this topic was once that of Krech et al. (1971a). In view of the fantastic advances within the virological, epidemiologic, and scientific wisdom of cytomegaloviruses, an updated e-book is required. any such paintings may still conceal many parts of craftsmanship and a voluminous technical literature. every one region could have been reviewed and analyzed via staff extra specialist than myself. even if, i've got launched into the whole enterprise by myself to be able to reach cohesion and continuity during this ebook, features that aren't simply accomplished within the extra well known multiauthored works. i've got attempted to check the literature and to supply a serious precis for every zone mentioned. to do that, I supply as a lot of the first info of the suitable works as wanted and never simply the qualitative conclusions. unavoidably, the circulate of the narrative can be interrupted by way of dry proof and figures. even if, such details is vital to make this a significant reference paintings. yet for these no longer drawn to such info, i've got supplied at what i'm hoping are an important issues evaluations and summaries. This e-book isn't an exhaustive assessment of the entire literature. this can be most likely now not attainable or maybe fascinating. by means of choice, notwithstanding, one runs the chance of getting neglected or missed very important papers. i'm keenly conscious of this, and that i desire to ask for forgiveness for such oversight, if that's possible.

Show description

Read Online or Download Cytomegalovirus: Biology and Infection PDF

Best infectious diseases books

Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century

Because the terrorist assault at the usa on September eleven, 2001 and next instances of anthrax in Florida and big apple urban, awareness has been keen on the specter of b- logical conflict and bioterrorism. organic conflict brokers are de? ned as “living org- isms, no matter what their nature, or contaminated fabric derived from them, that are used for h- tile reasons and meant to reason ailment or demise in guy, animals and crops, and count for his or her efforts at the skill to multiply in individual, animal or plant attacked.

Molecular Virology

The publication offers a finished evaluation at the wisdom of virus an infection suitable for people and animals. for every virus relations the molecular info of the virus particle and the viral replication cycle are defined. in relation to virus varieties with relevance for human and/or animal well-being the knowledge on molecular biology, genetics and virus-cell interplay are mixed with these relating, pathogenesis, epidemiology, clinics, prevention and treatment.

Basic Immunology: Functions and Disorders of the Immune System

During this up-to-date version of uncomplicated Immunology, the authors proceed to bring a transparent, smooth creation to immunology, making this the most obvious selection for today’s busy scholars. Their event as lecturers, path administrators, and academics is helping them to distill the center info required to appreciate this advanced box.

Zoonoses: Infectious Diseases Transmissible from Animals to Humans

Zoonoses are a power danger to the worldwide human healthiness this present day, greater than two hundred ailments happening in people and animals are identified to be at the same time transmitted. Classical infectious ailments, resembling rabies, plague, and yellow fever, haven't been eliminated regardless of significant efforts. New zoonotic ailments are at the elevate due worldwide stipulations similar to overpopulation, wars, and meals shortage, which facilitate human touch with rodents, stray animals, and their parasites.

Additional info for Cytomegalovirus: Biology and Infection

Example text

1980) detected by light microscopy early nuclear changes with development of inclusion subunits 24 hr after infection. The full development of such inclusions does not take place until much later, usually about 96 hr after infection. There is some uncertainty about how nucleocapsids become enveloped. Usually, no fully enveloped particles are observed in the nucleus, although both enveloped and naked nucleocapsids may be observed in the cytoplasm. The prevailing theory is that the envelope is acquired by the nucleocapsids from the nuclear membrane during egress from the nucleus (Stem and Friedman, 1960; Smith and De Harven, 1974).

According to Stinski (1978), protein synthesis following CMV infection may be divided into two stages. There is an early stage with a peak of synthesis that is predominantly (70-90%) host specific, although some specific viral proteins are also made. Specific viral DNA synthesis initiates a second stage of protein synthesis which is predominantly viral, but 40-50% of the protein synthesized is still of host origin. 2 Biochemical Events of CMV Replication Event Immediate early protein synthesis Early protein synthesis Induction of DNA polymerase Stimulation of cell DNA Viral DNA synthesis and late protein synthesis Synthesis of IgG receptors Hours after infection 0-4 2-20 20 20 15-72 36 26 Chapter 2 This mode of protein synthesis is quite different from HSV.

Lglml) added 5 hr after fusion inhibited the appearance of early antigen, but ara-C did not, suggesting that early antigen required protein but not DNA synthesis. It may be coded for by parental viral DNA. Infectious virus was produced in heterokaryons if the heterokaryons or the mouse cells used for fusion were treated with IUdR. In that case, both viral specific nuclear and cytoplasmic antigens were diffusely distributed in the cytoplasm and in the nucleus 3-4 days after fusion. Perhaps a late viral function was actively suppressed in the isolated mouse cell.

Download PDF sample

Rated 4.94 of 5 – based on 40 votes