By Monto Ho
Although there are many first-class present studies on one or one other element of cytomegalovirus, the final accomplished therapy of this topic was once that of Krech et al. (1971a). In view of the fantastic advances within the virological, epidemiologic, and scientific wisdom of cytomegaloviruses, an updated e-book is required. any such paintings may still conceal many parts of craftsmanship and a voluminous technical literature. every one region could have been reviewed and analyzed via staff extra specialist than myself. even if, i've got launched into the whole enterprise by myself to be able to reach cohesion and continuity during this ebook, features that aren't simply accomplished within the extra well known multiauthored works. i've got attempted to check the literature and to supply a serious precis for every zone mentioned. to do that, I supply as a lot of the first info of the suitable works as wanted and never simply the qualitative conclusions. unavoidably, the circulate of the narrative can be interrupted by way of dry proof and figures. even if, such details is vital to make this a significant reference paintings. yet for these no longer drawn to such info, i've got supplied at what i'm hoping are an important issues evaluations and summaries. This e-book isn't an exhaustive assessment of the entire literature. this can be most likely now not attainable or maybe fascinating. by means of choice, notwithstanding, one runs the chance of getting neglected or missed very important papers. i'm keenly conscious of this, and that i desire to ask for forgiveness for such oversight, if that's possible.
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1980) detected by light microscopy early nuclear changes with development of inclusion subunits 24 hr after infection. The full development of such inclusions does not take place until much later, usually about 96 hr after infection. There is some uncertainty about how nucleocapsids become enveloped. Usually, no fully enveloped particles are observed in the nucleus, although both enveloped and naked nucleocapsids may be observed in the cytoplasm. The prevailing theory is that the envelope is acquired by the nucleocapsids from the nuclear membrane during egress from the nucleus (Stem and Friedman, 1960; Smith and De Harven, 1974).
According to Stinski (1978), protein synthesis following CMV infection may be divided into two stages. There is an early stage with a peak of synthesis that is predominantly (70-90%) host specific, although some specific viral proteins are also made. Specific viral DNA synthesis initiates a second stage of protein synthesis which is predominantly viral, but 40-50% of the protein synthesized is still of host origin. 2 Biochemical Events of CMV Replication Event Immediate early protein synthesis Early protein synthesis Induction of DNA polymerase Stimulation of cell DNA Viral DNA synthesis and late protein synthesis Synthesis of IgG receptors Hours after infection 0-4 2-20 20 20 15-72 36 26 Chapter 2 This mode of protein synthesis is quite different from HSV.
Lglml) added 5 hr after fusion inhibited the appearance of early antigen, but ara-C did not, suggesting that early antigen required protein but not DNA synthesis. It may be coded for by parental viral DNA. Infectious virus was produced in heterokaryons if the heterokaryons or the mouse cells used for fusion were treated with IUdR. In that case, both viral specific nuclear and cytoplasmic antigens were diffusely distributed in the cytoplasm and in the nucleus 3-4 days after fusion. Perhaps a late viral function was actively suppressed in the isolated mouse cell.