Computer Models in Biomechanics: From Nano to Macro by Ali Ghavami, Erik Van der Giessen, Patrick R. Onck (auth.),

By Ali Ghavami, Erik Van der Giessen, Patrick R. Onck (auth.), Gerhard A. Holzapfel, Ellen Kuhl (eds.)

This e-book features a choice of papers that have been awarded on the IUTAM Symposium

on “Computer types in Biomechanics: From Nano to Macro” held at Stanford college, California, united states, from August 29 to September 2, 2011.

It comprises state of the art papers on:

- Protein and telephone Mechanics: coarse-grained version for opened up proteins, collagen-proteoglycan structural interactions within the cornea, simulations of mobile habit on substrates

- Muscle Mechanics: modeling methods for Ca2+–regulated delicate muscle contraction, tender muscle modeling utilizing continuum thermodynamical frameworks, cross-bridge version describing the mechanoenergetics of actomyosin interplay, multiscale skeletal muscle modeling

- Cardiovascular Mechanics: multiscale modeling of arterial diversifications by means of incorporating molecular mechanisms, cardiovascular tissue harm, dissection homes of aortic aneurysms, intracranial aneurysms, electromechanics of the guts, hemodynamic changes linked to arterial home improvement following aortic coarctation, patient-specific surgical procedure making plans for the Fontan procedure

- Multiphasic Models: solutes in hydrated organic tissues, reformulation of mix theory-based poroelasticity for interstitial tissue progress, tumor cures of mind tissue, home improvement of microcirculation in liver lobes, reactions, mass shipping and mechanics of tumor development, water shipping modeling within the mind, crack modeling of swelling porous media

- Morphogenesis, organic Tissues and Organs: mechanisms of mind morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive types for bone home improvement and mechanobiology, bridging scales in breathing mechanics

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References Buschmann MD, Grodzinsky AJ (1995) A molecular model of proteoglycan-associated electrostatic forces in cartilage mechanics. J Biomech Eng 2:179–192 Che J, Dzubiella J, Li B, McCammom JA (2008) Electrostatic free energy and its variations in implicit solvent models. J Phys Chem B 112:3058–3069 24 X. Cheng et al. Elliott GF, Hodson SA (1998) Cornea, and the swelling of polyelectrolyte gels of biological interest. Rep Math Phys 61:1325–1365 Fatt I (1968) Dynamics of water transport in the corneal stroma.

1981). C. A. Holzapfel Fig. 2 A: length-tension behaviors of swine carotid media, where maximal steady-state active tension is obtained at a certain optimal length L0 . , 1989). , 1981). 2 Length-Tension Relationship Smooth muscle is able to generate active tension over a broad range of muscle lengths. The active length-tension relationship has a parabolic behavior with maximal active tension at an optimal muscle length larger than the slack length, see Fig. 2A. In addition, Figs. 2B and C show the respective active stress development and stretch behavior during isometric stimulation and isotonic shortening for two different after-loads.

2005), but a conclusive dataset for a wide range of substrate stiffness values is currently unavailable. Our results not only agree qualitatively with many experimental findings, but have been calibrated quantitatively to the average force per post from Saez et al. (2005), where the stiffness of the posts is varied. This step enables us to assert that the cell model parameters used in our study are representative of the epithelial cells explored by Saez et al. (2005). The horseshoe focal adhesions on the post tops that we obtain in our simulations match the experimental images obtained by Tan et al.

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