Cell Death During HIV Infection by Andrew D. Badley

By Andrew D. Badley

With the intention to transcend immune-based treatments, researchers at the moment are contemplating the consequences of apoptosis dysregulation in the course of HIV-induced immunodeficiency. This paintings presents the 1st accomplished compendium of the development made in figuring out the method of mobile dying regarding HIV and the aptitude breakthroughs in remedy that provide a lot promise. Combining the paintings of greater than two-dozen most sensible researchers, this seminal quantity presents clinicians and researchers with an exceptional reference, whereas additionally serving as an incubator to stimulate destiny study. It explains the elemental biology concerned with apoptosis, explains its scientific effect in HIV, and examines the most recent healing techniques.

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If this approach is used to examine slides prepared from tissue culture cells, however, it is important to assess whether apoptotic cells are uniformly distributed throughout the slide. , small lymphocytes) must be carefully distinguished from apoptotic nuclei. 14 Accordingly, this cleavage pattern is not specific for any particular endonuclease but, instead, reflects the structure of chromatin. Because any nuclease that introduces DNA double-strand breaks will randomly yield this pattern when intact chromatin is digested,15–17 there has been considerable debate about the nature and identity of the nuclease responsible for the apoptotic DNA fragmentation.

153, 1265, 2001. 13. , 14, 2060, 2000. 14. L. , 10, 2859, 1996. 15. , Lindsten, T. , BCL2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis, Mol. Cell, 8, 705, 2001. 16. B. , Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death, Science, 292, 727, 2001. 17. R. , The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues, Mol. Cell, 6, 1389, 2000.

The Bcl2 family: regulators of the cellular life-or-death switch, Nat. Rev. Cancer, 2, 647, 2002. © 2006 by Taylor & Francis Group, LLC 32 Cell Death during HIV Infection 9. , Sadoul, R. , Inhibition of Bax channel-forming activity by Bcl-2, Science, 277, 370, 1997. 10. T. , Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations, J. Biol. , 272, 10777, 1998. 11. , Sanchez, B. , Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells, J.

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