By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD
In this up to date variation of Basic Immunology, the authors proceed to carry a transparent, glossy creation to immunology, making this the most obvious selection for today’s busy scholars. Their adventure as lecturers, path administrators, and academics is helping them to distill the middle details required to appreciate this advanced box. by utilizing high-quality illustrations, relevant medical situations, and concise, centred text, it’s a wonderfully accessible advent to the workings of the human immune method, with an emphasis on scientific relevance.
- Concise, clinically concentrated content is logically organized through mechanism for effective mastery of the material.
- Features an appendix of medical cases and CD molecules.
- Includes numerous full-color illustrations, helpful tables, and chapter outlines.
- Focus questions within every one bankruptcy are perfect for self-assessment and review.
- Key points bolded during the textual content make it effortless to find vital information.
- Presents info in a structure and elegance that maximizes usefulness to scholars and teachers learning drugs, allied health and wellbeing fields, and biology.
- Fully up-to-date content equips you with the most recent appropriate advances in immunology.
- Revised and updated artwork complements your visible studying of significant ideas and decreases the over the top actual information present in higher textbooks.
- Twelve brand-new animations to be had on Student Consult aid extra clarify complicated concepts.
- Student seek advice booklet model integrated with buy. This more advantageous booklet event gives you entry to the textual content, figures, pictures, thesaurus of immunology phrases, self-assessment questions, and references on numerous units.
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During this up-to-date variation of easy Immunology, the authors proceed to convey a transparent, sleek advent to immunology, making this the most obvious selection for today’s busy scholars. Their adventure as lecturers, path administrators, and teachers is helping them to distill the middle info required to appreciate this complicated box.
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Extra info for Basic Immunology: Functions and Disorders of the Immune System
ITAMs, which also are present in subunits of lymphocyte antigen receptor–associated signaling molecules, become phosphorylated on tyrosine residues when the receptors recognize their activating ligands. The phosphorylated ITAMs bind and promote the activation of cytosolic protein tyrosine kinases, and these enzymes phosphorylate, and thereby activate, other substrates in several different downstream signal transduction pathways, eventually leading to cytotoxic granule exocytosis and production of IFN-γ.
2-2). These receptors for PAMPs and DAMPs belong to several protein families. Toll-Like Receptors Toll-like receptors (TLRs) are homologous to a Drosophila protein called Toll, which was discovered for its role in the development of the fly and later shown to be essential for protecting flies against infections. Different TLRs are specific for different components of microbes (Fig. 2-3). TLR-2 recognizes several bacterial and parasitic glycolipids and peptidoglycans; TLR-3, -7, and -8 are specific for viral singlestranded and double-stranded RNAs; TLR-4 is specific for bacterial LPS (endotoxin); TLR-5 is specific for a bacterial flagellar protein called flagellin; and TLR-9 recognizes unmethylated CpG DNA, which is more abundant in microbial genomes than in mammalian DNA.
Although our discussion has been limited to the role of phagocytes in innate immunity, macrophages are also important effector cells in both the cell-mediated arm and the humoral arm of adaptive immunity, as discussed in Chapters 6 and 8, respectively. Dendritic Cells Dendritic cells respond to microbes by producing numerous cytokines that serve two main functions: they initiate inflammation and they stimulate adaptive immune responses. By sensing microbes and interacting with lymphocytes, especially T cells, dendritic cells constitute an important bridge between innate and adaptive immunity.