Autoantibodies by Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD

By Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD

Autoimmune ailments are characterised via the incidence of antibodies reacting with self-constituents of the physique. The totally up-to-date 3rd variation of Autoantibodies is an in-depth evaluate of the most autoantibodies pointed out in the past, with specific emphasis on those who demonstrate a diagnostic or prognostic medical worth.

The new version covers fresh medical advances, diagnostic recommendations, and healing applied sciences. every one bankruptcy is targeted on a unmarried relatives of autoantibodies. this significant reference includes old notes, definitions, origins and assets of antigens well-known genetic institutions, mediated pathogenic mechanisms, equipment of detection, in addition to scientific application (disease occurrence and organization, diagnostic price, sensitivity and specificity, prognostic value). this is often a terrific reference for a person interested by the sector of autoimmune ailments.

  • Presents all recognized, very important autoantibodies in one resource, concentrating on the antibodies wanted for autoimmune affliction diagnosis
  • Includes scientific functions for every autoantibody in addition to normal information
  • Organized by means of sickness and affliction kind, through autoantibody relations, and fully cross-referenced

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3]  Dedeoglu F. Drug-induced autoimmunity. Curr Opin Rheumatol 2009;21:547–51. [4]  Selmi C, Gershwin ME. The role of environmental factors in primary biliary cirrhosis. Trends Immunol 2009;30:415–20. [5]  Svendsen AJ, Hjelmborg JV, Kyvik KO, Houen G, Nielsen C, Skytthe A, et al. The impact of genes on the occurrence of autoantibodies in rheumatoid arthritis. A study on disease discordant twin pairs. J Autoimmun 2013;41:120–5. [6]  Robbins WC, Holman HR, Deicher H, Kunkel HG. Complement fixation with cell nuclei and DNA in lupus erythematosus.

NAbs have also a crucial influence on protecting the body against waste products [20]; it was shown that they bind apoptotic cells and thereby facilitate uptake by dendritic cells, preventing activation of the adaptive immune system by molecules released upon apoptosis that could facilitate autoimmune events [21,22]. It seems that NAbs fulfill an important role in homeostasis of the immune system, which appears to be confirmed also by the high rate of ­conservation among species [23,24]. Moreover, several regulatory mechanisms to avoid autoimmune reactions from B-1 cells have been demonstrated; in fact B-1 cells are also activated by antigen ­binding to their BCR and mature into IgM-producing, short-living plasma cells.

Autoimmun Rev 2006;5:89–92. [53] Padilla ND, van Vliet AK, Schoots IG, Valls SM, Maas MA, Peltenburg EE, et al. C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion. Surgery 2007;142:722–33. [54] Zhang M, Takahashi K, Alicot EM, Vorup-Jensen T, Kessler B, Thiel S, et al. Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. J Immunol 2006;177:4727–34. [55] Lai Y, Yu XP, Zhang Y, Tian Q, Song H, Mucignat MT, et al.

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