Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn

By Margaret Ackerman, Falk Nimmerjahn

Antibody Fc is the 1st unmarried textual content to synthesize the literature at the mechanisms underlying the dramatic variability of antibodies to persuade the immune reaction. The e-book demonstrates the significance of the Fc area, together with protecting mechanisms, effector phone kinds, genetic information, and variability in Fc area functionality. This quantity is a severe single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers in addition to graduate scholars in immunology and vaccinology.

Antibodies characterize the correlate of safety for varied vaccines and are the main quickly starting to be category of gear, with functions starting from melanoma and infectious sickness to autoimmunity. Researchers have lengthy understood the variable area of antibodies, that are answerable for antigen attractiveness, and will offer safety via blocking off the functionality in their goal antigen. in spite of the fact that, fresh advancements in our realizing of the security mediated by way of antibodies have highlighted the serious nature of the antibody consistent, or Fc area, within the organic job of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune structures, supplying specificity to quite a lot of innate effector cells. moreover, they supply a suggestions loop to control the nature of the immune reaction through interactions with B cells and antigen-presenting cells.

  • Clarifies the various mechanisms of IgG task on the point of the various version structures used, together with human genetic, mouse, and in vitro
  • Covers the function of antibodies in melanoma, infectious ailment, and autoimmunity and within the environment of monoclonal antibody treatment in addition to obviously raised antibodies
  • Color illustrations improve factors of the immune system

Show description

Read Online or Download Antibody Fc. Linking Adaptive and Innate Immunity PDF

Best infectious diseases books

Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century

Because the terrorist assault at the usa on September eleven, 2001 and next instances of anthrax in Florida and big apple urban, consciousness has been interested in the specter of b- logical struggle and bioterrorism. organic conflict brokers are de? ned as “living org- isms, no matter what their nature, or contaminated fabric derived from them, that are used for h- tile reasons and meant to reason sickness or demise in guy, animals and crops, and rely for his or her efforts at the skill to multiply in individual, animal or plant attacked.

Molecular Virology

The booklet offers a finished assessment at the wisdom of virus an infection suitable for people and animals. for every virus relatives the molecular info of the virus particle and the viral replication cycle are defined. relating to virus kinds with relevance for human and/or animal overall healthiness the information on molecular biology, genetics and virus-cell interplay are mixed with these bearing on, pathogenesis, epidemiology, clinics, prevention and treatment.

Basic Immunology: Functions and Disorders of the Immune System

During this up to date variation of simple Immunology, the authors proceed to convey a transparent, glossy creation to immunology, making this the most obvious selection for today’s busy scholars. Their event as lecturers, path administrators, and teachers is helping them to distill the middle info required to appreciate this complicated box.

Zoonoses: Infectious Diseases Transmissible from Animals to Humans

Zoonoses are a continual danger to the worldwide human wellbeing and fitness this present day, greater than 2 hundred illnesses happening in people and animals are recognized to be jointly transmitted. Classical infectious illnesses, comparable to rabies, plague, and yellow fever, haven't been eliminated regardless of significant efforts. New zoonotic ailments are at the bring up due international stipulations corresponding to overpopulation, wars, and nutrition shortage, which facilitate human touch with rodents, stray animals, and their parasites.

Additional info for Antibody Fc. Linking Adaptive and Innate Immunity

Example text

Legionella and Mycobacteria are intracellular pathogens that are associated with the pulmonary infections Legionnaires’ disease and tuberculosis, respectively. 91,92 These are obligate intracellular organisms dwelling in phagolysosomelike compartments in DCs without inducing cell maturation or activation. 93 Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies Streptococcus pyogenes, the organism associated with necrotizing fasciitis, secretes enzymes that abolish the interaction of antibodies with FcRs.

Neutralization of animal virus infectivity by antibody. Arch Virol 2007;152(6):1047–59. 105. Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC. Antibodies mediate intracellular immunity through tripartite motifcontaining 21 (TRIM21). Proc Nat Acad Sci USA 2010;107(46):19985–90. 106. Thompson BS, Moesker B, Smit JM, Wilschut J, Diamond MS, Fremont DH. A therapeutic antibody against West Nile virus neutralizes infection by blocking fusion within endosomes. PLoS Pathog 2009;5(5):e1000453.

A mechanistic basis for potent, glycoprotein B-directed γ-herpesvirus neutralization. J Gen Virol 2011;92 (Pt 9):2020–33. 109. Halstead SB, Mahalingam S, Marovich MA, Ubol S, Mosser DM. Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes. Lancet Infect Dis 2010;10(10):712–22. 110. Sun P, Bauza K, Pal S, Liang Z, Wu SJ, Beckett C, et al. Infection and activation of human peripheral blood monocytes by dengue viruses through the mechanism of antibody-dependent enhancement.

Download PDF sample

Rated 4.82 of 5 – based on 4 votes