Advances in Virus Research, Vol. 72 by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy

By Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy

Released on the grounds that 1953, Advances in Virus study covers a various diversity of in-depth reports supplying a priceless review of the present box of virology. The influence issue for 2006 is 3.48 putting it seventh within the hugely aggressive class of virology. * Contributions from major specialists * Informs and updates on the entire newest advancements within the box

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2001), and nutrition (Kalayanarooj and Nimmannitya, 2005; Thisyakorn and Nimmannitya, 1993). , specific genotypes and/or serotypes, viral structures, etc) may be important indicators of DENV virulence. Although no clear correlation has been established between specific genotypes or serotypes and virulence, epidemiological and phylogenetic evidence suggests that certain Asian DENV-2 genotypes are more virulent than American genotypes or those circulating in the South Pacific (Fig. , 1999). Similarly DENV-3 genotype III, which belongs to a genetically distinct clade (Fig.

2008c). , 2001) and moDCs (Cologna and Rico-Hesse, 2003), as well as to alter virulence for mice (Sanchez and Ruiz, 1996). The putative attenuating property of D390 is further enhanced in chimeras where the Asian genotype 30 -NCR is replaced with the American genotype 30 -NCR (Cologna and Rico-Hesse, 2003), suggesting a synergistic function. In summary, these observations suggest that the amino acid residue at E-390 may play an important role in determining key aspects of DENV phenotype, although further investigation is needed.

These analyses are the first to imply that the dynamics of mutation, replication and selection are similar for DENV-2 across its host range and suggest of rapid sylvatic DENV turnover (rapid generation of viral diversity) due to their high nucleotide substitution rates. Surprisingly, the large virus population sizes of endemic DENV-2 associated with hyperendemicity do not appear to have major impacts on evolutionary rates. C. Evolution of virulence 1. DEN animal models A major limitation in DENV research is the lack of suitable animal or in vitro models that recapitulate human disease and viremia.

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