Advances in Cancer Research, Vol. 77 by George F. Vande Woude, George Klein

By George F. Vande Woude, George Klein

Advances in melanoma study offers worthy details at the fascinating and fast-moving box of melanoma learn. the following once more, extraordinary and unique studies are awarded. Key beneficial properties * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and scientific Implications of the Erb/HER Signaling community of development issue Receptors * p53 and Human melanoma: the 1st 10000 Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal melanoma; Expression; functionality; and Prognostic price * an easy Modes for Carcinogenesis of Colorectal melanoma with Microsatellite Instability

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Although lymph node status per se is the major prognostic factor indicating future relapse, even in lymph node negative breast cancer 30% of patients will relapse. Thus, it is imperative to determine other prognostic indicators that could identify which patients may have a more aggressive disease that requires more intensive treatment. The amount of ErbB-2, especially when analyzed in relatively large groups of patients (Ͼ300 specimens), appears to predict clinical outcome in both node negative and node positive patients, and thus may serve as a useful indicator.

90, 181–192. Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors Leah N. Klapper,1 Mark H. Kirschbaum,2 Michael Sela,1 and Yosef Yarden2 2 1 Department of Immunology Department of Biological Regulation The Weizmann Institute of Science Rehovot 76100, Israel I. Introduction II. Clinical Aspects of ErbB Receptors A. Breast Cancer B. Gynecological Cancers C. Prostate Cancer D. Gastrointestinal Cancer E. Lung Cancer F. Head and Neck Cancer G. Kidney Cancer H.

One of the large families of receptors is that of the ErbB tyrosine kinases, which bind multiple neuregulins and other epidermal growth factor-like molecules. Certain ErbB members and their ligands are involved in human cancers of various origins. However, most of the clinical data relate to ErbB-2, a protein whose overexpression in subsets of carcinomas can predict poor prognosis. Although no ligand has so far been assigned to ErbB-2, recent biochemical evidence implies that this oncoprotein operates as a shared receptor subunit of other ErbBs.

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